St Gregory's parish lies in the heart of the city of Norwich, just to the north of the modern market place and at the eastern end of the row of churches lining St Benedict's street, the former Roman east-west route through the city. The parish was well-to-do with middle-class citizens rather dominating the populace. Given the parish's proximity to St Peter Mancroft the most prestigious church in the city there was no doubt some rub-off on the neighbouring area. Nowadays the parish is scantily inhabited as most of the population has departed the mediaeval centre and the area is largely a shopping and business district with numerous restaurants and pubs.

St Gregory's church stands on a shelving site between the relative heights of the market and the bend of the river Wensum below. The church is now redundant for worship and functions as an arts centre. The church is one of the older Norwich churches with many features from the Decorated period although all the window tracery is Perpendicular. The church has had many changes, it once possessed a spire but this was removed in the Victorian era. This era also saw the usual make-over which removed/masked many original features. The old triangular churchyard has been preserved as an open space forming a favoured spot for lunches despite the depredations of numerous urban pigeons.